If you're going to define your own column names in the code, I'd remove the first row of the csv which contains the titles. Otherwise your first row will be blank, as seen below
q).Q.fs[{`:newfile upsert delete DateTime from `Date`Time xcols update Time:DateTime.time,Date:DateTime.date from flip `DateTime`Ask`Bid!("ZFF";",")0:x}]`Book1.csv
1779j
q)load `newfile
`newfile
q)newfile
Date Time Ask Bid
--------------------------------------
2007.04.01 21:00:34.086 1.3374 1.3371
2007.04.01 21:00:40.029 1.3375 1.337
2007.04.01 21:01:36.029 1.3376 1.3373
2007.04.01 21:02:21.118 1.3376 1.3373
2007.04.01 21:02:23.084 1.3376 1.3373
2007.04.01 21:02:23.280 1.3376 1.3373
2007.04.01 21:02:25.060 1.33775 1.3373
2007.04.01 21:02:35.565 1.3376 1.3372
2007.04.01 21:02:38.767 1.33775 1.3373
2007.04.01 21:03:05.415 1.3376 1.3373
2007.04.01 21:03:05.503 1.3376 1.3373
2007.04.01 21:03:06.035 1.3376 1.3372
2007.04.01 21:03:07.038 1.3376 1.3373
2007.04.01 21:03:13.029 1.3376 1.3373
2007.04.01 21:03:18.917 1.3376 1.3372
2007.04.01 21:03:24.079 1.3376 1.3373
2007.04.01 21:03:24.409 1.3376 1.3373
2007.04.01 21:03:25.106 1.3376 1.3373
2007.04.01 21:03:27.075 1.3376 1.3373